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Premixed Calcium Phosphate Cement Pastes



Shozo Takagi, Laurence C. Chow, S Hirayama, A Sugawara


A self-hardening calcium phosphate cement (CPC-I), consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), has been shown in clinical studies to be efficacious as bone repair materials. The hardening time (HT) of the cement is about 30 min with water and 5 min with phosphate solution as the liquid, and hydroxyapatite (HA) forms as the major product. In recent years, additional CPCs that do not contain TTCP have been developed (CPC-II: a-tricalcium phosphate (TCP) and CaCO3; CPC-III: DCPA and Ca(OH)2). These cements harden in 10 min with the phosphate solution, and also form HA as the final product. The present study investigated the feasibility of formulating premixed glycerol-CPC pastes that are stable in a package, resist washout, and will harden only after being delivered to the defect site. Glycerol was used as the liquid because the CPC hardening reaction does not occur in a water-free environment. Hydroxypropyl methylcellulose (HMC) and Na2HPO4 were added to improve the cohesiveness of the pastes and accelerate cement hardening, respectively. The Newman-Kuels multiple comparison test indicated that the Na2HPO4 amount, not the HMC amount, significantly (P
Proceedings Title
The 6th World Biomaterials Congress
No. 2
Conference Dates
May 15-20, 2000
Conference Title
World Biomaterials Congress


dicalcium phosphate glycerol, hydroxyapatite, hydroxypropyl methylcellulose, physicochemical properties, self-hardening calcium phosphate cement, tetracalcium phosphate, thicalcium phosphate


Takagi, S. , Chow, L. , Hirayama, S. and Sugawara, A. (2003), Premixed Calcium Phosphate Cement Pastes, The 6th World Biomaterials Congress (Accessed May 23, 2024)


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Created November 1, 2003, Updated February 19, 2017