Osteocyte Enhancement of Angiogenesis In Vitro

Published

February 14, 2007

Author(s)

Erica Takai, Juan M. Taboas, Rocky Tuan, Steven D. Hudson

Abstract

It is well known that an intimate relationship exists between vascularization and bone formation during development and fracture healing, where new bone formation is preceded by local vascularization. A recent rat exercise model has demonstrated that mechanical loading induced increases in bone formation are also preceded by increased bone vascularization, and correlated to blood vessel number. However, the cellular cues that lead to increased or maintained vascularization of bone remain unclear. Specifically, it is not clear whether osteoblasts, osteocytes (OCY), and/or osteoclasts are involved in the recruitment of new vasculature. Since OCYs form extensive interconnected cellular networks throughout the bone tissue and respond to a variety of mechanical and chemical stimuli, they have been proposed to be the mechano/chemostat cells of bone tissue. Along these lines, osteoporotic bone, which has decreased OCY density and a disorganized osteocyte network, has reduced number of capillaries and fewer vessels closely apposed to the bone surface. Thus OCYs may play an important role in vascular recruitment both with and without mechanical loading. In this study we have examined the ability of OCYs subjected to various physiologic stimuli to enhance angiogenesis in vitro.

Proceedings Title

Annual Meeting of the Orthopaedic Research Society | 53rd | | Orthopaedic Research Society

Conference Dates

February 11-14, 2007

Conference Title

Transactions of Annual Meeting of the Orthopaedic Research Society

Pub Type

Conferences

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Keywords

angiogenesis, bone, co-culture, endothelial cell, mechanotransduction, osteocycle

Citation

Takai, E. , Taboas, J. , Tuan, R. and Hudson, S. (2007), Osteocyte Enhancement of Angiogenesis In Vitro, Annual Meeting of the Orthopaedic Research Society | 53rd | | Orthopaedic Research Society, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852664 (Accessed December 12, 2024)