Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Nucleobase Orientation and Ordering in Films of Single-Stranded DNA on Gold



D Y. Petrovykh, V Perez-Dieste, A Opdahl, H Y. Kimura-Suda, J M. Sullivan, Michael J. Tarlov, F J. Himpsel, L J. Whitman


The structure of single-stranded DNA (ssDNA) immobilized on surfaces is critical to applications exploiting the molecular recognition function of nucleic acids.1-3 Although traditional surface analysis can be applied to adsorbed biomolecules,1 the interpretation can be different than for simpler molecular films, such as self-assembled monolayers. Because of their molecular complexity, bio-surfaces tend to have much less long-range order compared with systems typically studied under ultra-high vacuum (UHV), so the analysis of spectroscopic signatures associated with local ordering, molecular interactions, and overall film structure is more challenging. It is also important to determine the degree of correspondence between the bio-surface structures determined ex-situ under ambient and UHV and those present in the original aqueous conditions.
Journal of the American Chemical Society
No. 1


Petrovykh, D. , Perez-Dieste, V. , Opdahl, A. , Kimura-Suda, H. , Sullivan, J. , Tarlov, M. , Himpsel, F. and Whitman, L. (2006), Nucleobase Orientation and Ordering in Films of Single-Stranded DNA on Gold, Journal of the American Chemical Society (Accessed May 29, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created January 10, 2006, Updated October 12, 2021