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Nucleobase Orientation and Ordering in Films of Single-Stranded DNA on Gold

Published

Author(s)

D Y. Petrovykh, V Perez-Dieste, A Opdahl, H Y. Kimura-Suda, J M. Sullivan, Michael J. Tarlov, F J. Himpsel, L J. Whitman

Abstract

The structure of single-stranded DNA (ssDNA) immobilized on surfaces is critical to applications exploiting the molecular recognition function of nucleic acids.1-3 Although traditional surface analysis can be applied to adsorbed biomolecules,1 the interpretation can be different than for simpler molecular films, such as self-assembled monolayers. Because of their molecular complexity, bio-surfaces tend to have much less long-range order compared with systems typically studied under ultra-high vacuum (UHV), so the analysis of spectroscopic signatures associated with local ordering, molecular interactions, and overall film structure is more challenging. It is also important to determine the degree of correspondence between the bio-surface structures determined ex-situ under ambient and UHV and those present in the original aqueous conditions.
Citation
Journal of the American Chemical Society
Volume
128
Issue
No. 1

Citation

Petrovykh, D. , Perez-Dieste, V. , Opdahl, A. , Kimura-Suda, H. , Sullivan, J. , Tarlov, M. , Himpsel, F. and Whitman, L. (2006), Nucleobase Orientation and Ordering in Films of Single-Stranded DNA on Gold, Journal of the American Chemical Society (Accessed May 29, 2024)

Issues

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Created January 10, 2006, Updated October 12, 2021