Nonparametric Inference for Balanced Randomization Designs

Published

March 1, 2007

Author(s)

Andrew L. Rukhin

Abstract

The properties of two balanced randomization schemes which allocate the known number of subjects among several treatments are compared. According to the first procedure, the so-called truncated multinomial randomization design, the allocation process starts with the uniform distribution, until a treatment receives the prescribed number of subjects, after which this uniform distribution switches to the remaining treatments, and so on. The second scheme, the random allocation rule, selects at random any assignment of the given number of subjects per treatment. The limiting behavior of these two procedures is shown to be quite different in the sense that for the random allocation rule the instant, at which a treatment gets its prescribed number of subjects, comes much later. The large sample distribution of standard permutation tests is obtained, and formulas for the accidental bias and for the selection bias of both procedures are derived.

Citation

Journal Of Statistical Planning And Inference

Volume

137

Issue

3

Pub Type

Journals

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Keywords

Accidental bias, Clinical trials, Load balancing, Multinomial trials, Normal order statistics, Permutation tests, Probability generating function, Selection bias, Stirlings numbers

Citation

Rukhin, A. (2007), Nonparametric Inference for Balanced Randomization Designs, Journal Of Statistical Planning And Inference, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=150414 (Accessed May 17, 2024)