Non-Uniform Sampling for All: More Spectral Quality, Less Measurement Time

Published

June 30, 2017

Author(s)

Frank Delaglio, Gregory S. Walker, Kathleen A. Farley, Raman Sharma, Jeffrey C. Hoch, Luke Arbogast, Robert Brinson, John Marino

Abstract

Nuclear Magnetic Resonance (NMR) spectroscopy is an indispensable tool in pharmaceutical science, with uses in drug discovery, development, and manufacturing. Non-Uniform Sampling (NUS) is an acquisition method for NMR experiments with two or more dimensions that skips some fraction of data that would usually be measured. NUS can reduce acquisition times by a factor of two or more, allowing routine measurements that would usually be deferred for overnight collection to be delivered on the same day instead, and making it possible to resolve signals that would not be practical to see otherwise, for faster, more effective structure elucidation. We illustrate an application of NUS to an example small molecule.

Citation

American Pharmaceutical Review

Pub Type

Journals

Keywords

NMR, spectral processing, Non Uniform Sampling

Citation

Delaglio, F. , Walker, G. , Farley, K. , Sharma, R. , Hoch, J. , Arbogast, L. , Brinson, R. and Marino, J. (2017), Non-Uniform Sampling for All: More Spectral Quality, Less Measurement Time, American Pharmaceutical Review (Accessed April 16, 2024)