Multiscale Correlative Measurements of Nanoparticles in Cells
Aric W. Sanders, Kavita M. Jeerage, Cindi Schwartz, Alexandra E. Curtin, Ann C. Chiaramonti Debay
Nanoparticles are emerging as invaluable tools in disease diagnosis, disease treatment and imaging contrast enhancement agents. The interactions of nanoparticles with host organisms are complex and affect biological systems over length scales that vary from the size of molecules to that of elephants. In order to understand these interactions between nanoparticles and biological life forms, a variety of imaging and measurement techniques are required. We present methodology to statistically catalog cellular development on the macroscale, to identify the location of nanoparticles in cellular cultures on the microscale, and to identify the interaction of cellular organelles and nanoparticles on the nanoscale.