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Microfluidic techniques for mechanical measurements of biological samples



Paul Salipante


The use of microfluidics to make mechanical property measurements is increasingly common. Fabrication of microfluidic devices has enabled various types of flow control and sensor integration at micrometer length scales to interrogate biological materials. For rheological measurements of biofluids, the small length scales are well suited to reach high rates and measurements can be made on droplet sized samples. The control of flow fields, constrictions, and external fields can be used in microfluidics to make mechanical measurements of individual bioparticle properties, often at high sampling rates. Microfluidics also enables measurement of bio-surfaces, such as the elasticity and permeability properties of layers of cells cultured in microfluidic devices.
Biophysics Reviews


Microfluidics, Mechanics, Rheology, Elasticity, Viscoelasticity, Biofluids, Cell Culture


Salipante, P. (2023), Microfluidic techniques for mechanical measurements of biological samples, Biophysics Reviews, [online],, (Accessed May 24, 2024)


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Created January 20, 2023, Updated January 23, 2023