Topical anesthesia has the ability to provide painless application of pain management medications for minor procedures such as venipuncture, particularly in the pediatric population. Liposomes have been proposed as a highly advantageous nanocarrier for dermal transport of drugs. Unlike conventional liposome preparation methods, which yield polydisperse populations of liposomes which are too large to passively transverse dermal layers (typically >80 nm), the recently developed microfluidic method for liposome synthesis provides an approach for producing nearly-monodisperse vesicles of tunable size which can achieve a range of size not achievable by traditional methods (approximately 40 nm and below). In this study, we have utilized a previously-demonstrated microfluidic method for continuous-flow synthesis of small, nearly-monodisperse liposomes and demonstrated size-dependent passive uptake into porcine dermal tissue.
Proceedings Title: TechConnect World, Summit and Innovation Showcase 2013
Conference Dates: May 12-16, 2013
Conference Location: National Harbor, MD
Pub Type: Conferences
nanoparticle, liposome, microfluidics, drug delivery