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Microfluidic Platform for Magnetic Nanoparticle Trapping and Detection

Published

Author(s)

Charles A. Little, John Pellegrino, Stephen E. Russek

Abstract

We evaluate giant magnetoresistance (GMR) sensors to trap and count small concentrations of magnetic nanoparticles (MNPs) within microfluidic flow. The device presented in this paper takes the novel approach of capturing and detecting MNPs utilizing the strong fringe-fields present on the periphery of the patterned sensor. The presence of MNPs manifests as a field shift in magnetoresistance (MR) curve. Tests of the device have shown a noticeable response for 30 nm nominal MNPs at a flow rate of 5 υL/min. Such a device would be beneficial for a number of bio-medical applications, including immunoassays and for monitoring filtration processes, where large sample fluid volumes and lowering MNP concentration sensitivities are required.
Citation
IEEE Transactions on Magnetics
Volume
49
Issue
7

Keywords

Giant magnetoresistance, Magnetic particles, Magnetic sensors, Microfluidics

Citation

Little, C. , Pellegrino, J. and Russek, S. (2013), Microfluidic Platform for Magnetic Nanoparticle Trapping and Detection, IEEE Transactions on Magnetics, [online], https://doi.org/10.1109/TMAG.2013.2251416 (Accessed February 20, 2024)
Created July 15, 2013, Updated November 10, 2018