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Microfluidic Platform for the Generation of Organic-Phase Microreactors



Zuzanna T. Cygan, J Cabral, Kathryn L. Beers, Eric J. Amis


Rapid prototyping photolithography of a thiolene based resin was used to fabricate microfluidic devices stable to aliphatic and aromatic organic solvents. The swelling of the thiolene resin in various organic solvents was quantified and the solvent resistance properties of these microfluidic devices are described. Discrete droplets of hexanes and toluene of uniform size were generated in a water matrix containing SDS surfactant (SDS = sodium dodecylsulfate). Variation of water and organic flow rate in the fluidic channels was used to control droplet size and separation, and droplet composition could be controlled by varying flow rates of two joined organic streams. Organic phase synthetic reactions within the droplets were demonstrated with the bromination of alkenes inside of droplets of benzene.
No. 8


droplet formation, microfluidics, microreactors, photolithography, solvent swelling


Cygan, Z. , Cabral, J. , Beers, K. and Amis, E. (2005), Microfluidic Platform for the Generation of Organic-Phase Microreactors, Langmuir (Accessed May 21, 2024)


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Created April 1, 2005, Updated February 19, 2017