Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Mechanical Stability of Collagen Fibril Networks

Published

Author(s)

Gordon A. Shaw, Dennis P. McDaniel, John T. Elliott, Alessandro Tona, Anne L. Plant

Abstract

Thin films of type 1 collagen fibril networks fabricated on alkanethiol-functionalized surfaces have been previously shown to provide an excellent protein matrix for cultured cells in applications such as drug toxicity studies and studies of cell signaling pathways. Cell phenotypic parameters, including cell morphology and rate of proliferation, can depend on the processing conditions used for fabrication of the protein films. The mechanical characteristics of the collagen fibril network appear to be particularly important, and as such, understanding the the mechanical properties of individual fibrils, as well as their interactions with each other and the underlying substrate is critical for assuring a predictable response from cells. In this study, scanning probe microscopy and instrumented indentation are used in conjunction with small force metrology to examine the mechanical properties of these collagen fibrils and fibril networks.
Conference Dates
November 28-12, 2005
Conference Location
Boston, MA
Conference Title
Material Research Society Symposium

Citation

Shaw, G. , McDaniel, D. , Elliott, J. , Tona, A. and Plant, A. (2005), Mechanical Stability of Collagen Fibril Networks, Material Research Society Symposium, Boston, MA (Accessed October 4, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created November 1, 2005, Updated February 19, 2017