Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Measurement and Standardization Challenges for Exosome-Based Delivery Vectors



Bryant C. Nelson, Lili Wang, Samantha D. Maragh, Paul C. DeRose, Elzafir B. Elsheikh, Wyatt N. Vreeland, Ionita Ghiran, Jennifer Jones


Extracellular vesicles (EVs), and in particular exosomes, have the potential to revolutionize the development and efficient delivery of clinical therapeutics. In this Perspective, we focus on providing a brief introduction to the landscape of exosome-based vectors that are being developed for the delivery of protein- and nucleic acid-based therapeutics. The Perspective represents our opinion on the most pressing measurement and standardization challenges that are limiting the translation of EVs from the bench to the clinic. Current challenges limiting the development of EVs for drug delivery are the lack of (1) standardized cell-based platforms for the production of EV-based therapeutics, (2) reference material EV preparations for establishing measurement assurance and (3) standardized measurement systems for determining the molecular composition of EVs.
Nanomedicine (London, England)


extracellular vesicles, exosomes, nucleic acids, protein delivery, gene delivery, drug delivery, protein and gene therapeutics, reference materials, characterization


Nelson, B. , Wang, L. , Maragh, S. , DeRose, P. , Elsheikh, E. , Vreeland, W. , Ghiran, I. and Jones, J. (2020), Measurement and Standardization Challenges for Exosome-Based Delivery Vectors, Nanomedicine (London, England), [online], (Accessed April 23, 2024)
Created September 3, 2020, Updated November 3, 2020