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Knowledge Integration for Bio-Threat Response



K Verspoor, O Bodenreider, P Karp, H Kelly, S Loranger, M Musen, Ram D. Sriram, C Wroe, C Joslyn, J Ambrosiano


Bio-threats require rapid analysis and response to prevent widespread consequences to the population. The inability to easily link and exploit biological knowledge for both human and automated analysis is a major limitation on the speed of complex knowledge development and bio-threat response. Today, linkage among the vast array of biological knowledge repositories is primarily by hand. Key requirements for smooth linkage of knowledge sources include shared ontologies of concepts and semantic relations, capabilities for unifying terminology and extracting meaningful relations from text, and inference mechanisms to link and unify heterogeneous databases. While research in all these areas continues, the gaps to the needed knowledge integration technologies are immense, and would benefit from co-ordinated cross-agency funding.
Proceedings Title
Los Alamos Technical Report, LA-UR-05-0907
Conference Location


automated analysis, bio-threat, bio-threat response, biological knowledge, knowledge integration


Verspoor, K. , Bodenreider, O. , Karp, P. , Kelly, H. , Loranger, S. , Musen, M. , Sriram, R. , Wroe, C. , Joslyn, C. and Ambrosiano, J. (2005), Knowledge Integration for Bio-Threat Response, Los Alamos Technical Report, LA-UR-05-0907, , USA, [online], (Accessed May 18, 2024)


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Created August 31, 2005, Updated October 12, 2021