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Instability of HPLC Solvents



Thomas J. Bruno


Solvents that are commonly used in high performance liquid chromatography frequently have inherent chemical instabilities that must be considered when designing an analysis, or in the interpretation of results [1-4] . In many cases, such solvents are obtainable with stabilizers added to control the instability or to slow the reaction. Reactive solvents that do not have stabilizers must be used quickly or be given proper treatment. In either case, it is important to understand that the solvents (as they may be used in an analysis) are not necessarily pure materials.
CRC Handbook of Chemistry and Physics - 96th Edition
Publisher Info
CRC Press, Boca Raton, FL


HPLC, Solvent


Bruno, T. (2015), Instability of HPLC Solvents, CRC Press, Boca Raton, FL (Accessed April 15, 2024)
Created June 9, 2015, Updated February 19, 2017