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Injectable and Rapid-Setting Calcium Phosphate Bone Cement With Dicalcium Phosphate Dihydrate



Elena F. Burguera, Hockin D. Xu, Michael Weir


Calcium phosphate cement (CPC) sets in-situ with intimate adaptation to the contours of defect surfaces, and forms an implant having a structure and composition similar to hydroxyapatite, the putative mineral in teeth and bones. The objective of the present study was to develop an injectable CPC using dicalcium phosphate dihydrate (DCPD) with a high solubility for rapid setting. Two agents were incorporated to impart injectability and fast-hardening to the cement: a hardening accelerator (sodium phosphate) and a gelling agent (hydroxypropyl methylcellulose, HPMC). The cement with DCPD was designated as CPCD, and the conventional cement was referred to as CPCA. At a sodium phosphate concentration of 0 mol/L, CPCA had a setting time of (82 6) min. In contrast, CPCD exhibited rapid setting with a time of (17 1) min. At 0.2 mol/L sodium phosphate, setting time for CPCD was (15 1) min, significantly faster than (40 2) min for CPCA (Tukey s at 0.95). Sodium phosphate decreased the paste injectability (measured as the paste mass extruded from the syringe divided by the original paste mass inside the syringe). However, the addition of HPMC dramatically increased the paste injectability. For CPCD, the injectability was increased from (65 12) % without HPMC to (98 1) % with 1 % HPMC. Injectability of CPCA was also doubled to (99 1) %. The rapid-setting and injectable CPCD possessed flexural strength and elastic modulus values overlapping the reported values for sintered porous hydroxyapatite implants and cancellous bone. In conclusion, the injectable CPCD, with rapid setting and a relatively high strength and elastic modulus, should help the graft to quickly attain strength and geometrical integrity within a short period of time postoperatively. Injectable CPCD may have potential for procedures involving defects with limited accessibility or narrow cavities, when there is a need for precise placement of the paste, and when using minimally invasive surgical techniques.
Journal of Biomedical Materials Research Part B-Applied Biomaterials


bone repair, calcium phosphate cement, hydroxyapatite, injectability, rapid setting


Burguera, E. , Xu, H. and Weir, M. (2005), Injectable and Rapid-Setting Calcium Phosphate Bone Cement With Dicalcium Phosphate Dihydrate, Journal of Biomedical Materials Research Part B-Applied Biomaterials, [online], (Accessed July 15, 2024)


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Created September 23, 2005, Updated February 17, 2017