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Injectable and Macroporous Calcium Phosphate Cement Scaffold



Hockin D. Xu, Michael Weir, Elena F. Burguera, A M. Fraser


Calcium phosphate cement (CPC) can be molded and self-harden in vivo to form resorbable hydroxyapatite with excellent osteoconductivity. The objective of this study was to develop an injectable, macroporous and strong CPC scaffold, and to investigate the effects of porogen and absorbable fiber contents on the injectability and mechanical properties of the cement. Water-soluble mannitol particles were used as the porogen and mixed with the CPC powder at mannitol mass fractions of 0 %, 20 %, 30 %, 40 % and 50 %. The cement liquid contained sodium phosphate as a hardening accelerator and hydroxypropyl methylcellulose as a gelling agent. CPC with mannitol fractions of 0 % to 40 % were fully injected under an injection force of less than 10 N. However, the paste with 50 % mannitol required a force of 100 N which extruded only 66 % of the paste mass. The pastes at 1.5 min to 15 min after the start of mixing were completely extruded; however, the injection force at 15 min increased to (50.2 14.6) N, significantly higher than the injection forces at 1.5 min to 10 min (p


bone repair, calcium phosphate cement, injectability, macroporous scaffold, strength


Xu, H. , Weir, M. , Burguera, E. and Fraser, A. (2006), Injectable and Macroporous Calcium Phosphate Cement Scaffold, Biomaterials, [online], (Accessed May 25, 2024)


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Created August 1, 2006, Updated February 17, 2017