Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes
David Worcester, Michael Weinrich
Neutron diffraction measurements demonstrate that hydrostatic pressure promotes Liquid-ordered (L0) domain formation in lipid membranes of both oriented multi-layers and unilamellar vesicles made of a canonical ternary lipid mixture for which demixing transitions have been extensively studied. The results demonstrate an unusually large dependence of the mixing transition temperature on hydrostatic pressure and provide a plausible explanation for the reversal of general anesthesia by hydrostatic pressure.
Lipid Domains, Demixing transitions, Hydrostatic Pressure, General Anesthesia
and Weinrich, M.
Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes, Journal of Physical Chemistry Letters, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=918601
(Accessed December 7, 2023)