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Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes



David Worcester, Michael Weinrich


Neutron diffraction measurements demonstrate that hydrostatic pressure promotes Liquid-ordered (L0) domain formation in lipid membranes of both oriented multi-layers and unilamellar vesicles made of a canonical ternary lipid mixture for which demixing transitions have been extensively studied. The results demonstrate an unusually large dependence of the mixing transition temperature on hydrostatic pressure and provide a plausible explanation for the reversal of general anesthesia by hydrostatic pressure.
Journal of Physical Chemistry Letters


Lipid Domains, Demixing transitions, Hydrostatic Pressure, General Anesthesia


Worcester, D. and Weinrich, M. (2015), Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes, Journal of Physical Chemistry Letters, [online], (Accessed June 13, 2024)


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Created October 22, 2015, Updated February 19, 2017