Worcester, D.
and Weinrich, M.
(2015),
Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes, Journal of Physical Chemistry Letters, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=918601
(Accessed October 28, 2025)
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Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes
Published
Author(s)
, Michael Weinrich
Abstract
Neutron diffraction measurements demonstrate that hydrostatic pressure promotes Liquid-ordered (L0) domain formation in lipid membranes of both oriented multi-layers and unilamellar vesicles made of a canonical ternary lipid mixture for which demixing transitions have been extensively studied. The results demonstrate an unusually large dependence of the mixing transition temperature on hydrostatic pressure and provide a plausible explanation for the reversal of general anesthesia by hydrostatic pressure.Citation
Journal of Physical Chemistry Letters
Volume
6
Pub Type
Journals
Download Paper
Keywords
Lipid Domains, Demixing transitions, Hydrostatic Pressure, General Anesthesia
Citation
Issues
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Created October 22, 2015, Updated February 19, 2017