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Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes

Published

Author(s)

David Worcester, Michael Weinrich

Abstract

Neutron diffraction measurements demonstrate that hydrostatic pressure promotes Liquid-ordered (L0) domain formation in lipid membranes of both oriented multi-layers and unilamellar vesicles made of a canonical ternary lipid mixture for which demixing transitions have been extensively studied. The results demonstrate an unusually large dependence of the mixing transition temperature on hydrostatic pressure and provide a plausible explanation for the reversal of general anesthesia by hydrostatic pressure.
Citation
Journal of Physical Chemistry Letters
Volume
6

Keywords

Lipid Domains, Demixing transitions, Hydrostatic Pressure, General Anesthesia

Citation

Worcester, D. and Weinrich, M. (2015), Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes, Journal of Physical Chemistry Letters, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=918601 (Accessed June 13, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created October 22, 2015, Updated February 19, 2017