Human Mitochondrial Protein Database: A Resource for Human Mitochondrial Proteomics

Published

October 12, 2021

Author(s)

Veerasamy Ravichandran, A S. Khan, Peter E. Barker, G B. Vasquez, S J. Zullo, Talapady N. Bhat, G L. Gilliland

Abstract

A publicly available web-based resource, the Human Mitochondrial Protein Database (HMPD), has been developed to unify data from a broad collection of related resources that provides information about human nuclear and mitochondrial-encoded proteins. This resource is designed to address the problem presented by the increasing amount, complexity and types of proteomics data available in public databases. At this point in time, no systematically established correlations between the different types of data have been established that allows meaningful comparisons. One of the primary reasons for this is the lack of data standards. Despite this, a wealth of data exists and is readily available from numerous web resources that is applicable to proteomics and have direct relevance to identifying proteins and assigning function. However, serious problems with the interactions between these resources arise because of problems with data exchange and interoperability. Although public proteomics data resources are highly informative, individually, the collection of available content would have more utility if provided in a standard and centralized context and indexed in a robust manner for a specialized area. HMPD currently consolidates information from SwissProt (http://www.ebi.ac.uk/swissprot/), LocusLink (http://www.ncbi.nlm.nih.gov/LocusLink/), the Protein Data Bank (PDB; http://nist.rcsb.org/pdb/), GenBank (http://www.ncbi.nlm.nih.gov/), the Genome Database (GDB; http://gdbwww.gdb.org/), Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/omim/), Human Mitochondrial Genome Database (mtDB; http://www.genpat.uu.se/mtDB/), MITOMAP (http://www.mitomap.org/), Neuromuscular Disease Center (http://www.neuro.wustl.edu/neuromuscular/mitosyn.html), Human 2-D PAGE database (http://proteomics.cancer.dk/jecelis/human_data_select.html), among others. The human mitochondrial protein database is available at http://bioinfo.nist.gov:8080/examples/servlets/index.html

Citation

Nucleic Acids Research

Pub Type

Journals

Keywords

data interoperability, data standards, Mitochondrion, Protemics

Citation

Ravichandran, V. , Khan, A. , Barker, P. , Vasquez, G. , Zullo, S. , Bhat, T. and Gilliland, G. (2021), Human Mitochondrial Protein Database: A Resource for Human Mitochondrial Proteomics, Nucleic Acids Research (Accessed October 12, 2024)