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Histopathological Reactions of Calcium Phosphate Cements in Periodontal Bone Defect



K Fujikawa, A Sugawara, S K. Kusama, S Murai, M Nishiyama, I Moro, Shozo Takagi, Laurence Chow


Previous studies have demonstrated that a calcium phosphate cement (CPC), consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), and a new calcium phosphate cement (N-CPC), consisting of [alpha]-tricalcium phosphate (TCP) and calcium carbonate, are highly biocompatible and osteoconductive. Although CPC and N-CPC have the potential to be suitable materials for periodontal bone grafts, there have been no studies that documented bone dynamics relevant to the healing of the defect sites in conjunction with the placements of CPC or N-CPC under the conditions that correspond to periodontal healing. The purpose of this study was to determine the histological aspects of CPC and N-CPC compared with those of a hydroxyapatite (Hap) material, by grafting the materials into artificially formed periodontal bone defects using a dog model. One and 6 months after surgery, the dogs were sacrificed and the tissues that included the experimental materials were excised enblock. One month after surgery, the control site, where the pocket was not filled with any materials, showed new cementum formation just coronal to the instrumented root surface. Six months after surgery, the Hap particle were surrounded by newly formed bony tissues. The osseous defect was mostly placed by bony tissue. A small amount of CPC material was still observed in the pocket, but most of the pocket space was occupied by normal bone tissues. Defect sites filled with N-CPC were completely occupied by the newly formed compact alveolar bone and the pockets were covered by dense fibrous connective tissues.
Society for Biomaterials


bone defect, calcium phosphate, cement, histopathology, osteoconductivity, periodontology


Fujikawa, K. , Sugawara, A. , Kusama, S. , Murai, S. , Nishiyama, M. , Moro, I. , Takagi, S. and Chow, L. (1995), Histopathological Reactions of Calcium Phosphate Cements in Periodontal Bone Defect, Society for Biomaterials (Accessed June 17, 2024)


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Created June 13, 1995, Updated October 12, 2021