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High-Throughput Investigation of Cell Proliferation on Crystalline Polymers



N. R. Washburn, S B. Kennedy, Carl Simon Jr., K Yamada, Eric J. Amis


The results of our investigation of cell proliferation on crystalline polymers will be presented. The goal of the research is to investigate how cells respond to nanometer scale roughness, and crystallizing poly(L-lactic acid) (PLLA) was a convenient system on which to study this. It appears that substrate roughness can strongly influence the rate of proliferation of cells. Enzyme-linked immunofluorescent assays were performed to investigate whether there is any significant change in the concentration or conformation of adsorbed attachment proteins such as vitronectin or fibronectin and found none. It appears that these cells are responding strictly to the surface topography.
Conference Dates
April 1, 2003
Conference Location
Conference Title
Transactions of the Society for Biomaterials


cell-material interactions, high-throughput methodologies, polymers


Washburn, N. , Kennedy, S. , Simon Jr., C. , Yamada, K. and Amis, E. (2003), High-Throughput Investigation of Cell Proliferation on Crystalline Polymers, Transactions of the Society for Biomaterials, Undefined, [online], (Accessed April 24, 2024)
Created March 31, 2003, Updated October 12, 2021