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Heat capacity and decomposition of rimantadine hydrochloride



Ala Bazyleva, Yauheni Paulechka, Dzmitry H. Zaitsau, Andrey V. Blokhin, Gennady J. Kabo


Heat capacities of antiviral drug rimantadine hydrochloride in the crystalline state were measured by adiabatic calorimetry and differential scanning calorimetry in the temperature range from (7 to 453) K. A broad low-enthalpy solid-state phase anomaly was detected between (170 and 250) K. Thermodynamic functions for crystalline rimantadine hydrochloride were derived. Decomposition of the studied compound was probed by the Knudsen effusion method and thermogravimetry with a support of quantum chemical calculations. The enthalpy of decomposition of rimantadine hydrochloride into the corresponding amine and hydrogen chloride was estimated from those data. The thermodynamic functions of the corresponding amine in the ideal gaseous state, including enthalpy of formation, were obtained by the statistical thermodynamics with the necessary molecular parameters computed using quantum chemical methods. Enthalpy of formation of crystalline rimantadine hydrochloride was estimated.
Thermochimica ACTA


Rimantadine chloride, heat capacity, thermodynamic properties, decomposition, effusion, thermogravimetric analysis, quantum-chemistry calculations


Bazyleva, A. , Paulechka, Y. , Zaitsau, D. , Blokhin, A. and Kabo, G. (2020), Heat capacity and decomposition of rimantadine hydrochloride, Thermochimica ACTA, [online], (Accessed May 30, 2024)


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Created January 29, 2020, Updated July 1, 2020