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Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 Hours After a Sodium Fluoride Monofluorophosphate Rinse



Gerald L. Vogel, Y Mao, Laurence C. Chow, H M. Proskin


Sodium monofluorophosphate (NaMFP) and sodium fluoride (NaF) are the two most common sources of fluoride used in currently marketed fluoride dentifrices. The purpose of this study was to investigate the effect of mouth rinses containing NaF or NaMFP on the concentrations of fluoride, in saliva, whole plaque, and plaque fluid. Twelve subjects abstained from tooth brushing 48 h, fasted overnight, and rinsed 1 min with 12 mmol/L (228 ppm [ g/g] F) NaF or NaMFP in the morning. Before the rinse and at 30, 60 and 120 min afterwards, upper and lower molar and premolar plaque samples and whole saliva sample were collected. Aliquots of plaque fluid and clarified saliva were obtained from these samples, and the whole plaque residue acid extracted. The F and MFP concentrations were then measured in these samples using ultramicro methods. For both rinses, a higher concentration of plaque fluid fluoride was found at lower molar sites while the reverse was true for the whole plaque fluoride. Furthermore, for both rinses, plaque fluid, whole plaque, but not salivary, fluoride concentrations were above baseline at 120 min. Following the NaMFP rinse, a substantial amount of unhydrolyzed MFP was found in plaque fluid and saliva. Although there was a very large range in these measurements, fluoride in plaque fluid (excluding fluoride in unhydrolyzed MFP) and whole plaque were significantly (p
Caries Research
No. 5


fluoride, plaque, plaque-fluid, rinse, saliva


Vogel, G. , Mao, Y. , Chow, L. and Proskin, H. (2000), Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 Hours After a Sodium Fluoride Monofluorophosphate Rinse, Caries Research, [online], (Accessed June 21, 2024)


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Created September 1, 2000, Updated February 17, 2017