Fabrication of Shape Specific Biodegradable Porous Polymeric Scaffolds With Controlled Interconnectivity by Solid Free-Form Microprinting
E Jabbari, K W. Lee, A C. Ellison, M J. Moore, John A. Tesk, M J. Yazemski
Standards for the characterization of scaffolds useful for tissue engineering are an ongoing development in Division IV of the ASTM. Terminology refers to porosity and interconnectivity, but definitions that uniquely define these terms do not exist. Several NIST workshops have identified the need for reference scaffolds and characterization of their porosity and interconnectivity will be needed. To help move toward resolving these needs, several scaffolds with known geometry were fabricated for evaluation. Rapid prototyping (RP) was used for fabrication of polymer scaffolds with well defined and reproducible architecture.Models of cubic orthogonal geometry were created. Struts, 600 m in size were designed to intersect at 90 angles to create a matrix of connected cubic pores. The distances between the struts were varied to make three different pore sizes: (300, 600, and 900) m. The scaffolds had randomly chosen faces of pores closed off to create varying degrees of interconnectivity corresponding to (10, 20 and 30) % of closed faces. These will be evaluated by NIST using combined optical coherence tomography (OCT) and optical coherence fluorescence microscopy (OCFM) and colleagues at the Mayo Clinic will evaluate them by other means, including mercury intrusion porosimetry and density measurements. This paper confirms the ability to produce scaffolds with the needed features.
Transactions of the 7th World Biomaterials Congress
, Lee, K.
, Ellison, A.
, Moore, M.
, Tesk, J.
and Yazemski, M.
Fabrication of Shape Specific Biodegradable Porous Polymeric Scaffolds With Controlled Interconnectivity by Solid Free-Form Microprinting, Transactions of the 7th World Biomaterials Congress, Sidney, 1, AS, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852316
(Accessed December 3, 2023)