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Evaluation of the effect of donor variability on stem cell response to biomaterials

Published

Author(s)

Stephen J. Florczyk, Bryan A. Baker, Sumona Sarkar, Jennifer H. McDaniel, Patrick S. Pine, Marc L. Salit, Carl G. Simon Jr.

Abstract

Previous research from our group indicated that nanofiber scaffolds promoted osteogenic differentiation of human bone marrow stromal cells (hBMSC) and similar gene expression to osteogenic supplement (OS) induced osteogenic differentiation [1]. Biological variation between hBMSC donors can result in differences in cell response to materials. To advance tissue engineering treatments into the clinic and to develop robust characterization of cell-material interactions, the response to materials for several donors needs to be characterized. In this study, we examined the cell response to five material groups (three material substrates and two substrates plus OS) for six hBMSC donors evaluated by differences in gene expression.
Proceedings Title
Society for Biomaterials 2014 Annual Meeting & Exposition
Volume
1
Issue
1
Conference Dates
April 16-19, 2014
Conference Location
Denver, CO

Keywords

nanofiber, bone marrow stromal cell, osteogenic differentiation
Created April 19, 2014, Updated February 19, 2017