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Erosion Mechanism of Polyanhydrides Containing Oligomeric Ethylene Glycol

Published

Author(s)

Brandon M. Vogel, Maria D. Torres, Surya Mallapragada, Balaji Narasimhan

Abstract

Polyanhydrides are biodegradable polymers that have proved to be excellent drug carriers. Applications of these polymers to protein-based drug delivery systems have been scarce. A suitable carrier may be created by incorporating hydrophilic entities into highly hydrophobic polyanhydrides. A novel method was developed to introduce oligomeric ethylene glycol into aromatic polyanhydrides. This paper focuses on the synthesis, characterization and erosion studies of copolymers of the polyanhydride poly(1,6-bis(p-carboxyphenoxy)hexane) (CPH), which is highly hydrophobic, and poly(1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane) (CPTEG), which has hydrophilic oligomeric ethylene glycol chains in the backbone. The thermal properties of the polymers make them suitable for processing conditions during drug incorporation. Erosion studies demonstrate that by increasing CPH content in CPTEG:CPH copolymers, the system erosion can be tailored from bulk to surface mechanism.
Citation
Journal of the Biomedical Research Society

Keywords

biodegradable, drug delivery, erosion, polyanhydride

Citation

Vogel, B. , Torres, M. , Mallapragada, S. and Narasimhan, B. (2008), Erosion Mechanism of Polyanhydrides Containing Oligomeric Ethylene Glycol, Journal of the Biomedical Research Society (Accessed May 18, 2024)

Issues

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Created October 16, 2008