Erosion Mechanism of Polyanhydrides Containing Oligomeric Ethylene Glycol
Brandon M. Vogel, Maria D. Torres, Surya Mallapragada, Balaji Narasimhan
Polyanhydrides are biodegradable polymers that have proved to be excellent drug carriers. Applications of these polymers to protein-based drug delivery systems have been scarce. A suitable carrier may be created by incorporating hydrophilic entities into highly hydrophobic polyanhydrides. A novel method was developed to introduce oligomeric ethylene glycol into aromatic polyanhydrides. This paper focuses on the synthesis, characterization and erosion studies of copolymers of the polyanhydride poly(1,6-bis(p-carboxyphenoxy)hexane) (CPH), which is highly hydrophobic, and poly(1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane) (CPTEG), which has hydrophilic oligomeric ethylene glycol chains in the backbone. The thermal properties of the polymers make them suitable for processing conditions during drug incorporation. Erosion studies demonstrate that by increasing CPH content in CPTEG:CPH copolymers, the system erosion can be tailored from bulk to surface mechanism.
Journal of the Biomedical Research Society
biodegradable, drug delivery, erosion, polyanhydride
, Torres, M.
, Mallapragada, S.
and Narasimhan, B.
Erosion Mechanism of Polyanhydrides Containing Oligomeric Ethylene Glycol, Journal of the Biomedical Research Society
(Accessed October 3, 2023)