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Engineering Ligands for Characterizing Biomaterials Using Combinatorial Phage Display

Published

Author(s)

Marc Roy, Eric J. Amis, Matthew Becker

Abstract

Recently, combinatorial phage display has emerged as a powerful method to design peptides capable of selective and enhanced binding affinity to organic, inorganic and ion-doped polyelectrolytes. This approach offers significant advantages over de novo peptide design in the number of peptides that can be screened and the speed with which the evaluation of their affinity and specificity proceed. We have focused on and will describe recent efforts in which we have identified peptide sequences demonstrating enhanced and specific binding characteristics to crystalline inorganic substrates, such as hydroxyapatite and thin polymer films of degradable polymers.
Proceedings Title
ACS 234th National Meeting & Exposition
Conference Dates
August 22, 0007-August 25, 2007
Conference Location
Boston , MA

Keywords

biomaterials, combinatorial phage display, ELISA, hydroxyapatite, material specific peptides, poly(DTE)

Citation

Roy, M. , Amis, E. and Becker, M. (2007), Engineering Ligands for Characterizing Biomaterials Using Combinatorial Phage Display, ACS 234th National Meeting & Exposition, Boston , MA (Accessed June 16, 2024)

Issues

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Created August 22, 2007, Updated February 19, 2017