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Engineered metal nanoparticles in the sub-nanomolar levels kill cancer cells



Yasmine C. Daniels, William A. MacCrehan, Shinichiro Muramoto, Gheorghe NMN Stan, Vitaly Vodyanoy, Oleg Pustovyy


Zinc and copper metal nanoparticles were produced from bulk metal rods by an underwater high-voltage discharge method. The metal nanoparticles, with estimated diameters of 1 nm to 2 nm, were determined to be more than 85 % non-oxidized. Exposure of rat RG2 glioma cancer cells to these nanoparticles resulted in morphological cell changes, including decreased cell adherence, shrinking/rounding, nuclear condensation and budding from cell bodies. The nanoparticles were lethal for the cells at the sub-nanomolar concentrations.
Nanomedicine: nanotechnology, biology, and medicine


nanoparticles, xps, glioma cancer cell, apoptosis
Created April 18, 2016, Updated November 10, 2018