Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Engineered metal nanoparticles in the sub-nanomolar levels kill cancer cells



Yasmine C. Daniels, William A. MacCrehan, Shinichiro Muramoto, Gheorghe NMN Stan, Vitaly Vodyanoy, Oleg Pustovyy


Zinc and copper metal nanoparticles were produced from bulk metal rods by an underwater high-voltage discharge method. The metal nanoparticles, with estimated diameters of 1 nm to 2 nm, were determined to be more than 85 % non-oxidized. Exposure of rat RG2 glioma cancer cells to these nanoparticles resulted in morphological cell changes, including decreased cell adherence, shrinking/rounding, nuclear condensation and budding from cell bodies. The nanoparticles were lethal for the cells at the sub-nanomolar concentrations.
Nanomedicine: nanotechnology, biology, and medicine


nanoparticles, xps, glioma cancer cell, apoptosis


Daniels, Y. , MacCrehan, W. , Muramoto, S. , , G. , Vodyanoy, V. and Pustovyy, O. (2016), Engineered metal nanoparticles in the sub-nanomolar levels kill cancer cells, Nanomedicine: nanotechnology, biology, and medicine, [online], (Accessed April 14, 2024)
Created April 18, 2016, Updated November 10, 2018