Effect of Surface Chemistry on Stem Cell Response in 2-D vs. 3-D Cell Culture Niches

Abstract

To develop tissue engineered devices for regenerative medicine strategies, key scaffold properties for directing stem cell response must be identified. As focus shifts from 2-D to 3-D culture systems in an attempt to better recapitulate the natural cellular environment, traditional strategies to enhance the cell culture environment may no longer have equivalent effects on cells. The synergistic effects of the new 3-D culture environments are largely undetermined.