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Effect of Solvent Quality on the Molecualr Dimensions of PAMAM Dendrimers



A Topp, Barry J. Bauer, D A. Tomalia, Eric J. Amis


The average dimensions of poly (amido amine) (PAMAM) dendrimers of generation numbers G5 and G8 are measured by small angle neutron scattering as a function of solvents of different quality, of the composition of mixtures of a good solvent and a non-solvent, and of temperature. The radius of gyration of the G8 dendrimer, Rg, decreases for the series of solvents D(CD2)mOD (with m = 0, 1, 2, 4) by approximately 10 % with decreasing solvent quality. The amount of swelling of PAMAM dendrimers, as reflected by Rg, is not influenced by the composition of mixtures of methyl alcohol/acetone in the full range of solubility of the dendrimers. In the temperature range - 10 degrees {Celsius} g value. The average segment densities are calculated for G5 and G8 under various solvent conditions, with the dendrimers containing volume fractions of solvent between 0.43 and 0.60.
No. 21


dendrimer, PAMAM, radius of gyration, SANS, solvent


Topp, A. , Bauer, B. , Tomalia, D. and Amis, E. (1999), Effect of Solvent Quality on the Molecualr Dimensions of PAMAM Dendrimers, Macromolecules (Accessed April 20, 2024)
Created October 1, 1999, Updated February 17, 2017