Effect of Powder Grinding on Hydroxyapatite Formation in a Polymeric Calcium Phosphate Cement Prepared from Tetracalcium Phosphate and Poly[Methyl Vinyl Ether-Maleic Acid]

Published

November 1, 1998

Author(s)

Y Matsuya, S Matsuya, Joseph M. Antonucci, S. Takagi, Laurence C. Chow, A Akamine

Abstract

The primary aim of this study was to determine if cement based on poly(methyl vinyl ether-maleic acid) (PMVE-Ma) and tetracalcium phosphate (TTCP) resulted in hydroxyapatite (OHAp) formation. In addition, the mechanical strength of this type of polymeric calcium phosphate cement was evaluated.Cements were prepared by mixing, in a powder/liquid mass ratio of 3.0, an aqueous solution of PMVE-Ma (mass fraction = 25%) and tetracalcium phosphate powders ground for various periods of time. The Tetracalcium phosphate powders and set cements were characterized by means of x-ray powder diffraction and scanning electron microscopy. Mechanical strengths of the cements were tested 24 h after mixing. Prolonged grinding of tetracalcium phosphate powder decreased particle size and /or crystallite size and increased lattice distortion. This enhanced the reactivity of the Tetracalcium phosphate powder and elevated the extent of crosslinking between PMVE-Ma molecules, resulting in improved mechanical strength. Hydroxyapatite formation was detected in the cement prepared with the most finely ground Tetracalcium phosphate powder. The conversion of residual Tetracalcium phosphate particles to thermodynamically stable hydroxyapatite crystals will reduce the solubility of the polymeric cement and increase its biocompatibility.

Citation

Biomaterials

Volume

20

Pub Type

Journals

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Keywords

acid-base reaction, hydroxyapatite, particle size, poly (vinyleter-maleic acid), tetracalcium phosphate, x-ray analysis, Dentistry

Citation

Matsuya, Y. , Matsuya, S. , Antonucci, J. , Takagi, S. , Chow, L. and Akamine, A. (1998), Effect of Powder Grinding on Hydroxyapatite Formation in a Polymeric Calcium Phosphate Cement Prepared from Tetracalcium Phosphate and Poly[Methyl Vinyl Ether-Maleic Acid], Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851419 (Accessed October 13, 2025)