Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Effect of Charged Lidocaine on Static and Dynamic Properties of Model Bio-Membranes



Zheng Yi, Michihiro Nagao, Dobrin P. Bossev


The effect of the charged lidocaine on the structure and dynamics of DMPC/DMPG (mass fraction of 95/5}) unilamellar vesicles has been investigated. Changes in membrane organization caused by the presence of lidocaine were detected through small angle neutron scattering experiments. Our results suggest that the presence of lidocaine in the vicinity of the headgroups of lipid membranes leads to increase of the area per lipid molecule and to decrease of membrane thickness. Such changes in membrane structure may induce disordering of the tail group. This scenario explains the reduction of the main transition temperature of lipid membranes, as the fraction of lidocaine per lipid molecules increases, which was evident from differential scanning calorimetry results. Furthermore neutron spin echo spectroscopy was used for the dynamics measurements and the results reveal that presence of charged lidocaine increases the bending elasticity of the lipid membranes in the fluid phase and slows the temperature-dependent change of bending elasticity across the main transition temperature.
Biophysical Chemistry


lipid, bilayer, dynamics, lidocaine


Yi, Z. , Nagao, M. and Bossev, D. (2012), Effect of Charged Lidocaine on Static and Dynamic Properties of Model Bio-Membranes, Biophysical Chemistry, [online], (Accessed May 26, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created December 31, 2011, Updated October 12, 2021