An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Dynamic SIMS Utilizing SF5+ Polyatomic Primary Ion Beams for Drug Delivery Applications
Published
Author(s)
Christine M. Mahoney, S V. Roberson, John G. Gillen
Abstract
The behavior of various biodegradable polymer films (e.g. polylactic acid, polyglycolic acid and polycaprolactone) as well as some model drugs (theophylline and 4-acetamidophenol) under dynamic SF5+ primary ion bombardment is explored. A series of polylactic acid films containing varying concentrations of 4-acetamidophenol are also analyzed under similar conditions. The resultant molecular depth profiles obtained from these polymer films doped with drug show very little degradation in molecular signal as a function of SF5+ primary ion dose, and it was found that the molecular ion signals of both polymer and drug remained constant for ion doses up to ~5x1015 ions/cm2. In addition, the polymer film / Si interface was well defined which may imply that sputter-induced topography formation was not a significant limitation. These results suggest that the structure of the biodegradable polymers studied here which all have the common structural unit, R-CO-O-R, allows for a greater ability to depth profile due to ease of bond cleavage. Most importantly however, these results indicate that in these particular polymer systems, the distribution of the drug as a function of depth can be monitored.
Citation
Applied Surface Science
Volume
231-232
Issue
Sp.
Pub Type
Journals
Keywords
cluster, depth profile, drug delivery, SF<sub>5</sub><sup>+</sup>, TOF-SIMS
Mahoney, C.
, Roberson, S.
and Gillen, J.
(2004),
Dynamic SIMS Utilizing SF<sub>5</sub><sup>+</sup> Polyatomic Primary Ion Beams for Drug Delivery Applications, Applied Surface Science
(Accessed October 7, 2024)