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Discrimination Between Wild-Type and Ampicillin-Resistant Escherichia coli by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Published

Author(s)

Johanna Camara

Abstract

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was optimized to discriminate between wild-type and ampicillin-resistant Escherichia coli. Only ampicillin-resistant E. coli displayed an m/z 29000 peak, potentially representing B lactamase. Rapid MALDI-TOF MS detection of antibiotic-resistance could fulfill an important clinical need, providing critical phenotypic information beyond genus-species identification.
Citation
Journal of Microbiological Methods

Keywords

antibiotic resistance, B-lactamase, Escherichia coli, MALDI-TOF MS

Citation

Camara, J. (2008), Discrimination Between Wild-Type and Ampicillin-Resistant Escherichia coli by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, Journal of Microbiological Methods (Accessed May 29, 2024)

Issues

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Created October 16, 2008