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Controlled Release from Model Blend Multilayer Films Containing Mixtures of Strong and Weak Polyelectrolytes



Yeongseon Jang, Bulent Akgun, Hosub Kim, Sushil K. Satija, Kookheon Char


We have designed the controlled relase platforms based on polyelectrolyte (PE) blend multilayer films to investigate the release mode and kinetics and the nanoscale level. The model blend multilayer films are composed of positively charged layers with weak polyelectrolytes (PEs) (linear poly(ethylenimine), LPEI) and negatively charged blend layers with mixtures of strong (poly(sodium-4-styrene sulfonic acis), PSS) and weak (poly(methacrylic acid), PMAA) PEs. The blend multilayer films ([LPEI/PSS:PMAA]n) with well-defined internal structure were prepared by the spin-assisted layer-by-layer (LbL) deposition method. Release properties of the multilayer films were systematically studied as a function of blend ration by neutron reflectivity (NR), ellipsometer, AFM, FT-IR spectroscopy, and quartz crystal microbalance with dissipation (QCM-D). Since PSS strong PEs serve as robust skeletons within the multilayer films independent of external pH variation, the burst disruption of pure weak PE multilayer films was dramatically suppressed and the release kinetics could be accurately controlled by simply changed the PSS content within the blend films. These release properties of blend multilayer films form the basis for designing the controlled release of target active materials from surfaces.


controlled release, Polyelectrolyte multilayers, neutron reflectivity, QCM, pH-responsive films, blends


Jang, Y. , Akgun, B. , Kim, H. , Satija, S. and Char, K. (2012), Controlled Release from Model Blend Multilayer Films Containing Mixtures of Strong and Weak Polyelectrolytes, Macromolecules, [online], (Accessed May 28, 2024)


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Created April 2, 2012, Updated October 12, 2021