An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Controlled Protein Release From High-Strength Calcium Phosphate Cement-Chitosan Composites
Published
Author(s)
Michael Weir, Hockin D. Xu
Abstract
Calcium phosphate cement (CPC) can conform to complex cavity shapes and set in situ to form bioresorbable hydroxyapatite. The aim of this study was to develop a mechanically-strong CPC with protein release; and to control protein release via microstructural tailoring. Chitosan content and powder to liquid ratio were systematically varied to enhance the mechanical properties of protein-containing CPC, and to control the protein release. Fluorescently-labeled Protein A from Sigma (St. Louis, MO) was used as a model compound to study the protein/growth factor release. Protein release was defined as mass of released protein/mass of total protein incorporated into the specimen. When the chitosan content was increased from 0 % to 10 % and 15 %, the protein released from CPC (mean sd; n = 6) was varied significantly from (0.60 0.03) to (0.41 0.04), and to (0.23 0.07), respectively (p
bone regeneration, calcium phosphate cement, chitosan, elastic modulus, protein release, strength
Citation
Weir, M.
and Xu, H.
(2007),
Controlled Protein Release From High-Strength Calcium Phosphate Cement-Chitosan Composites, Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852676
(Accessed February 7, 2025)