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Controlled Protein Release From High-Strength Calcium Phosphate Cement-Chitosan Composites



Michael Weir, Hockin D. Xu


Calcium phosphate cement (CPC) can conform to complex cavity shapes and set in situ to form bioresorbable hydroxyapatite. The aim of this study was to develop a mechanically-strong CPC with protein release; and to control protein release via microstructural tailoring. Chitosan content and powder to liquid ratio were systematically varied to enhance the mechanical properties of protein-containing CPC, and to control the protein release. Fluorescently-labeled Protein A from Sigma (St. Louis, MO) was used as a model compound to study the protein/growth factor release. Protein release was defined as mass of released protein/mass of total protein incorporated into the specimen. When the chitosan content was increased from 0 % to 10 % and 15 %, the protein released from CPC (mean sd; n = 6) was varied significantly from (0.60 0.03) to (0.41 0.04), and to (0.23 0.07), respectively (p


bone regeneration, calcium phosphate cement, chitosan, elastic modulus, protein release, strength


Weir, M. and Xu, H. (2007), Controlled Protein Release From High-Strength Calcium Phosphate Cement-Chitosan Composites, Biomaterials, [online], (Accessed April 19, 2024)
Created August 9, 2007, Updated February 17, 2017