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Complex by Design: Hydrotrope-Induced Micellar Growth in Deep Eutectic Solvents



Adrian Sanchez-Fernandez, Anna E. Leung, Elizabeth Kelley, Andrew J. Jackson


Here the microstructure of hydrotrope-surfactant assemblies in 1:2 choline chloride:glycerol (ChCl:Glyc) is presented. The effect of choline salicylate (ChSal) on the micellization of hexadecyltrimethylammonium chloride (C16TAC) was investigated by contrast-variation small-angle neutron scattering (SANS). The microscopic characterization of the system shows that the micelle-hydrotrope interaction in pure and hydrated deep eutectic solvents (DES) results in a significant increase in micelle elongation, leading to the formation of worm-like micelles (WLM) with tunable morphology and flexibility. The results presented here open new possibilities in terms of self-assembly and co-assembly in neoteric solvents, where micelle morphology can be controlled through surfactant-hydrotrope interactions.
Journal of Colloid and Interface Science
Part A


Deep eutectic solvents, surfactant, hydrotrope, worm-like micelles


Sanchez-Fernandez, A. , Leung, A. , Kelley, E. and Jackson, A. (2021), Complex by Design: Hydrotrope-Induced Micellar Growth in Deep Eutectic Solvents, Journal of Colloid and Interface Science (Accessed November 29, 2023)
Created December 31, 2020, Updated September 7, 2021