Comparison of Classical and MALDI-TOF-MS Analysis of a Polystyrene Interlaboratory Sample

Published

January 1, 1999

Author(s)

William R. Blair, B M. Fanconi, R J. Goldschmidt, Charles M. Guttman, William E. Wallace, S Wetzel, David L. VanderHart

Abstract

Over the past several years, the use of MALDI-TOF-MS for analysis of synthetic polymers has increased significantly. As the number of polymer analyses by MALDI has increased, scrutiny of the MALDI results in comparison to classically derived values for Mw, Mn and MWD, defined as the mass average molecular mass, the number average molecular mass and the molar mass distribution, respectively, has resulted. The results of MALDI and classical analysis do not always agree. In anticipation of the need for reference standards for calibration and intercomparison of current and future MALDI analytical methods, NIST has initiated an intercomparison of Mn and Mw determinations by MALDI.

Proceedings Title

Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics Proceedings

Volume

399

Conference Dates

June 13-17, 1999

Conference Location

Dallas, TX

Conference Title

ASMS Conference on Mass Spectrometry and Allied Topics

Pub Type

Conferences

Download Paper

Local Download

Keywords

interlaboratory comparison, MALDI, MALDI-TOF-MS, polystyrene

Citation

Blair, W. , Fanconi, B. , Goldschmidt, R. , Guttman, C. , Wallace, W. , Wetzel, S. and VanderHart, D. (1999), Comparison of Classical and MALDI-TOF-MS Analysis of a Polystyrene Interlaboratory Sample, Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics Proceedings, Dallas, TX, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851607 (Accessed October 17, 2025)