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Comparison of Classical and MALDI-TOF-MS Analysis of a Polystyrene Interlaboratory Sample

Published

Author(s)

William R. Blair, B M. Fanconi, R J. Goldschmidt, Charles M. Guttman, William E. Wallace, S Wetzel, David L. VanderHart

Abstract

Over the past several years, the use of MALDI-TOF-MS for analysis of synthetic polymers has increased significantly. As the number of polymer analyses by MALDI has increased, scrutiny of the MALDI results in comparison to classically derived values for Mw, Mn and MWD, defined as the mass average molecular mass, the number average molecular mass and the molar mass distribution, respectively, has resulted. The results of MALDI and classical analysis do not always agree. In anticipation of the need for reference standards for calibration and intercomparison of current and future MALDI analytical methods, NIST has initiated an intercomparison of Mn and Mw determinations by MALDI.
Proceedings Title
Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics Proceedings
Volume
399
Conference Dates
June 13-17, 1999
Conference Location
Dallas, TX
Conference Title
ASMS Conference on Mass Spectrometry and Allied Topics

Keywords

interlaboratory comparison, MALDI, MALDI-TOF-MS, polystyrene

Citation

Blair, W. , Fanconi, B. , Goldschmidt, R. , Guttman, C. , Wallace, W. , Wetzel, S. and VanderHart, D. (1999), Comparison of Classical and MALDI-TOF-MS Analysis of a Polystyrene Interlaboratory Sample, Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics Proceedings, Dallas, TX, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=851607 (Accessed June 20, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created December 31, 1998, Updated October 12, 2021