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Combinatorial Synthesis and Dissolution Testing of Polyanhydride Copolymers



Brandon M. Vogel, Naomi Eidelman, Surya Mallapragada, Balaji Narasimhan


A linearly varying compositional library of 100 different polyanhydride randomcopolymers was designed, fabricated, and characterized within a few hours. A subset of this library was chosen and a substrate was designed and fabricated to enable the synthesis and monitoring of dye dissolution from a range of polyanhydride copolymers, in a parallel fashion, using a CCD camera. Multi-sample substrates were fabricated with a novel rapid prototyping method that consists of an (organic-solvent resistant) array of 10 10 microwells of 2 l volume each. The libraries were deposited with a custom-built liquid dispensing system, consisting of a series of computer-controlled volume dispensing pumps and XYZ motion stages. Copolymers of 1,6-bis(p-carboxyphenoxy) hexane (CPH) and sebacic anhydride (SA) were characterized with infrared microspectroscopy to determine the composition within a well. The methodology described in this work is amenable to numerous applications in the arenas of high-throughput polymer synthesis and characterization.
Journal of the American Chemical Society


biodegradable, combinatorial, drug delivery, high-throughput, parallel synthesis, polyanhydride, rapid prototyping


Vogel, B. , Eidelman, N. , Mallapragada, S. and Narasimhan, B. (2005), Combinatorial Synthesis and Dissolution Testing of Polyanhydride Copolymers, Journal of the American Chemical Society (Accessed June 17, 2024)


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Created August 28, 2005, Updated February 17, 2017