Combinatorial Synthesis and Dissolution Testing of Polyanhydride Copolymers
Brandon M. Vogel, Naomi Eidelman, Surya Mallapragada, Balaji Narasimhan
A linearly varying compositional library of 100 different polyanhydride randomcopolymers was designed, fabricated, and characterized within a few hours. A subset of this library was chosen and a substrate was designed and fabricated to enable the synthesis and monitoring of dye dissolution from a range of polyanhydride copolymers, in a parallel fashion, using a CCD camera. Multi-sample substrates were fabricated with a novel rapid prototyping method that consists of an (organic-solvent resistant) array of 10 10 microwells of 2 l volume each. The libraries were deposited with a custom-built liquid dispensing system, consisting of a series of computer-controlled volume dispensing pumps and XYZ motion stages. Copolymers of 1,6-bis(p-carboxyphenoxy) hexane (CPH) and sebacic anhydride (SA) were characterized with infrared microspectroscopy to determine the composition within a well. The methodology described in this work is amenable to numerous applications in the arenas of high-throughput polymer synthesis and characterization.
Journal of the American Chemical Society
biodegradable, combinatorial, drug delivery, high-throughput, parallel synthesis, polyanhydride, rapid prototyping
, Eidelman, N.
, Mallapragada, S.
and Narasimhan, B.
Combinatorial Synthesis and Dissolution Testing of Polyanhydride Copolymers, Journal of the American Chemical Society
(Accessed December 10, 2023)