Chatterjee, K.
, Young, M.
and Simon Jr., C.
(2011),
Combinatorial Screening of Hydrogel Scaffolds for 3D Cell Culture, Artech House, Norwood, MA
(Accessed June 3, 2023)
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Combinatorial Screening of Hydrogel Scaffolds for 3D Cell Culture
Published
Author(s)
, Marian F. Young,
Abstract
Optimizing cell-material interactions is critical towards maximizing regeneration in tissue engineering. Combinatorial and high-throughput (CHT) methods can be used to systematically screen tissue scaffolds to identify optimal biomaterial properties. Previous CHT platforms in tissue engineering have involved a two-dimensional (2D) cell culture format where cells were cultured on material surfaces. However, these platforms are inadequate to predict cellular response in a three-dimensional (3D) tissue scaffold. We describe a simple CHT platform to screen cell-material interactions in 3D culture format that can be applied to screen hydrogel scaffolds. Herein we focus on a method to prepare gradients in elastic modulus of photopolymerizable hydrogels.Citation
Methods In Bioengineering
Publisher Info
Artech House, Norwood, MA
Pub Type
Books
Keywords
combinatorial methods, high-throughput screening, hydrogels, elastic modulus, gradients, osteoblast, tissue engineering
Citation
Created May 1, 2011, Updated October 12, 2021