Combinatorial and High-throughput Screening of Biomaterials
Carl Simon Jr., Sheng Lin-Gibson
The review describes recent advances in utilizing combinatorial and high-throughput methods to better understand cell-material interactions, in terms of cell toxicity, adhesion, morphology, migration, proliferation and differentiation, particularly highlighting our work at NIST Polymers Division in these areas. The utility of combinatorial and high-throughput methods and their unique advantages over traditional one-at-a-time approaches are discussed. We conclude by noting additional opportunities for combinatorial methods for biomaterials research including streamlined sample fabrication and characterization, appropriate and automated bioassays, and data analysis packages. Some perspectives for the utility of combinatorial methods for biomaterials research will be provided.