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Co-Nonsolvency of Poly(n-isopropylacrylamide) in Deuterated Water/Ethanol Mixtures



Michael-Jon A Hore, Boualem Hammouda, Yuyan Li, He Cheng


Small-angle neutron scattering was used to investigate poly(N-isopropylacrylamide) (PNIPAM) polymer solutions in d-water /d-ethanol mixtures. A wide poor-solvent region was observed for mixtures near 60 % d-water/40 % d-ethanol mixture. Spinodal lines were determined, permitting a mapping of the mixing/demixing regions of the phase diagram which comprises two main branches: the left branch (with mostly d-ethanol) where phase separation occurs upon cooling (UCST) and the right branch (with mostly d-water) where phase separation occurs upon heating (LCST). The ternary random phase approximation model was used to analyze SANS data. Three Flory-Huggins interaction parameters (PNIPAM/d-water, PNIPAM/d-ethanol and d-water/d ethanol) were obtained. These display the reassuring 1/T behavior but show strong dependence on d-water/d-ethanol fraction. The conformation of polymer chains was determined by monitoring of the radius of gyration. Chains tend to swell with increasing temperature except close to the boundary of the left branch of the phase diagram (40 % d-water) where they are observed to shrink.


PNIPAM , small-angle neutron scattering , random phase approximation , phase diagram


, M. , Hammouda, B. , Li, Y. and Cheng, H. (2013), Co-Nonsolvency of Poly(n-isopropylacrylamide) in Deuterated Water/Ethanol Mixtures, Macromolecules, [online], (Accessed July 16, 2024)


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Created September 25, 2013, Updated February 19, 2017