Chemically Modifiable Fluorinated Copolymer Nanoparticles for 19F MRI Contrast Enhancement
Jessica L. Staymates, Mark M. Bailey, Steven R. Kline, Michael D. Anderson, Cory Berkland
Recently there has been interest in developing imaging contrast media for magnetic resonance imaging (MRI) that contain biologically rare, magnetically active nuclei such as fluorine. In principle, fluorinated contrast agents can be used to generate highly-selective 19F magnetic resonance images that can be superimposed over complimentary 1H magnetic resonance images to provide an anatomical context for the fluorinated contrast agent. Additionally, nanoparticles can be made to target various pathological sites via active and passive targeting mechanisms. In this study, fluorinated nanoparticles were produced using a free radical polymerization of vinyl formamide monomers with two different fluorinated monomers. The nanoparticles showed a clear, single 19F-NMR signal. Additionally, surface amide groups were hydrolyzed to primary amines to yield additional surface reactivity. Fluorinated nanoparticles produced using a free radial polymerization method yield a new nanoparticle for 19F magnetic resonance imaging applications with potential for facile functionalization.
, Bailey, M.
, , S.
, Anderson, M.
and Berkland, C.
Chemically Modifiable Fluorinated Copolymer Nanoparticles for 19F MRI Contrast Enhancement, Langmuir, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=907253
(Accessed October 3, 2023)