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Characterization of Laminin on Silanized Polydimethylsiloxane



Joy P. Dunkers, Lisa M. Hughes, Hae-Jeong Lee, Marvi Matos, Marcus T. Cicerone


In this work, we characterize a protein surface on a flexible polydimethylsiloxane substrate (PDMS) capable of undergoing strain. We compare the results from two different surface treatments: physically adsorbed laminin on PDMS and laminin deposited on silane treated PDMS. Immunofluorescence and x-ray reflectivity were used to measure the amount of laminin from each surface treatment. Vascular smooth muscle cell attachment and proliferation were compared between the methods. Additional work will concentrate on evaluating the robustness of surface treatments under strain.
Conference Dates
August 17-21, 2008
Conference Location
Philadelphia, PA
Conference Title
ACS Fall Meeting


laminin, polydimethylsiloxane, smmoth muscle cells, X-ray reflectivity


Dunkers, J. , Hughes, L. , Lee, H. , Matos, M. and Cicerone, M. (2008), Characterization of Laminin on Silanized Polydimethylsiloxane, ACS Fall Meeting, Philadelphia, PA, [online], (Accessed June 24, 2024)


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Created August 21, 2008, Updated February 19, 2017