Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Chapter 154. Choline | Properties and Determination



Melissa M. Phillips


Choline is an essential nutrient that is required for normal cell function, with involvement in numerous cellular processes. Choline can be produced via de novo biosynthesis, but must be complimented with dietary intake to support optimum health. Foods highest in total choline content include egg yolks, liver (from beef, veal, chicken, turkey), and wheat germ. In order to properly assign levels of choline in foods to establish intakes, as well as in body fluids to evaluate health status, appropriate analytical methods that are both accurate and precise should be used. Classical and current methodologies are discussed.
Encyclopedia of Food and Heatlh


Choline, phosphatidylcholine, acetylcholine, hydrolysis, betaine, biomarker, folate, metabolism, methylation, extraction, phosphocholine, sphingomyelin, glycerophosphocholine


Phillips, M. (2016), Chapter 154. Choline | Properties and Determination, Encyclopedia of Food and Heatlh, [online], (Accessed February 22, 2024)
Created December 31, 2015, Updated November 10, 2018