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Catalyst Enabled in Situ Linkage Reduction in Imine Covalent Organic Frameworks



Jiyun Hu, Federica Zanca, Gregory McManus, Isabella Riha, Huong Giang Nguyen, William Shirley, Collin Borcik, Benjamin Wylie, Mourad Benamara, Roger van Zee, Peyman Moghadam, M. Hassan Beyzavi


New linkages for covalent organic frameworks (COFs) have been continuously pursued by chemists as it serves as the structure and property foundation for the materials. Developing new reaction types or modifying known linkages have been the only two methods to create new COF linkages. Herein we report a novel strategy that uses H3PO3 as a bifunctional catalyst to achieve amine linked COFs from readily available amine and aldehyde linkers. The acidic proton of H3PO3 catalyzes the imine framework formation which is then in situ reduced to the amine COF by the reductive P-H moiety. The amine linked COF outperforms its imine analogue in promoting Knoevenagel condensation because of the more basic sites and higher stability.
ACS Applied Materials and Interfaces


Hu, J. , Zanca, F. , McManus, G. , Riha, I. , , H. , Shirley, W. , Borcik, C. , Wylie, B. , Benamara, M. , van, R. , Moghadam, P. and , M. (2021), Catalyst Enabled in Situ Linkage Reduction in Imine Covalent Organic Frameworks, ACS Applied Materials and Interfaces, [online],, (Accessed July 17, 2024)


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Created April 29, 2021, Updated May 13, 2021