Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Archaeal DNA replication



Zvi Kelman, Lori M. Kelman


DNA replication is an essential process for all life forms. While the process is fundamentally conserved in the three domains of life, bioinformatics, biochemical, structural and genetic studies have demonstrated that the process and the proteins involved in archaeal replication are much closer to those in eukarya than to bacteria, with some archaeal-specific features. Similar to bacteria and eukarya, the archaeal replication system is not monolithic and there are some differences in the replication process between different species. In this review the current knowledge of the mechanisms governing DNA replication in archaea is summarized. The general features of the replication process as well as some of the differences are discussed.
Annual Review of Genetics


archaea, initiation of DNA replication, protein-DNA interactions, protein-protein interactions, regulation of DNA replication, protein structure


Kelman, Z. and Kelman, L. (2014), Archaeal DNA replication, Annual Review of Genetics, [online], (Accessed April 18, 2024)
Created November 3, 2014, Updated November 10, 2018