U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Application of Ion-Impact Energy Measurement to Electrospray Ionization Mass Spectrometry of Proteins and Protein Mixtures

Published

Author(s)

B. Neuhauser, Gene C. Hilton, John M. Martinis

Abstract

We have used normal metal-insulator-superconductor (NIS) microcalorimeter to measure the impact energy of protein ions produced by electrospray ionization (ESI) in a magnetic-sector mass spectrometer (MS). We have used these measurements to resolve spectral ambiguities and to analyze protein mixtures. Energy measurement may be useful for the direct MS analysis of complex biopolymer mixtures that normally would confound ESI-MS deconvolution algorithms.
Citation
Journal of the American Society for Mass Spectrometry
Volume
12
Pub Type
Journals

Citation

Neuhauser, B. , Hilton, G. and Martinis, J. (2001), Application of Ion-Impact Energy Measurement to Electrospray Ionization Mass Spectrometry of Proteins and Protein Mixtures, Journal of the American Society for Mass Spectrometry (Accessed October 13, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created December 31, 2000, Updated October 12, 2021