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Analytical Gaps and Challenges for Particles in the Submicrometer Size Domain



Scott Aldrich, Shawn Cao, Andrea Hawe, Desmond Hunt, Linda Narhi, Dean C. Ripple, Satish Singh


This Stimuli article provides a technical discussion of the available technologies for submicrometer particle analysis, including consideration of the advantages, disadvantages, and technical gaps for each application. These methods can be used in the characterization of different protein aggregates as well as other types of particles in this size range. Changes are occurring rapidly in this field, so the article and discussions focus on measurement principles and comparisons rather than specific instruments.
Pharmacopeial Forum


Biopharmaceutical, Light Scattering, Nanoparticle Tracking Analysis, Particles, Protein, Resonance Mass Measurement, Silicone Oil


Aldrich, S. , Cao, S. , Hawe, A. , Hunt, D. , Narhi, L. , Ripple, D. and Singh, S. (2016), Analytical Gaps and Challenges for Particles in the Submicrometer Size Domain, Pharmacopeial Forum, [online], (Accessed April 21, 2024)
Created November 30, 2016, Updated October 13, 2022