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Amorphous Calcium Phosphate/Urethane Methacrylate Resin Composites. I. Physicochemical Characterization



William Regnault, Tonya Icenogle, Joseph M. Antonucci, Drago Skrtic


Urethane dimethacrylate (UDMA), an oligomeric poly(ethylene glycol) UDMA (PEG-U) and a blend of UDMA/PEG-U were chosen as model systems for introducing both hydrophobic and hydrophilic segments and a range of compliances into their derived polymers. Experimental composites based on these three resins with amorphous calcium phosphate (ACP) as the filler phase were polymerized and evaluated for mechanical strength and ion release profiles in different aqueous media. Strength of all composites decreased upon immersion in saline (pH = 7.4). Both polymer matrix composition and the pH of the liquid environment strongly affected the ion release kinetics. In saline, the UDMA/PEG-U composite showed a sustained release for at least 350 h. The initially high ion release of the PEG-U composites decreased after 72 h, seemingly due to the mineral re-deposition at the composite surface. Internal conversion from ACP to poorly crystallized apatite could be observed by X-ray diffraction. In various lactic acid (LA) environments (initial pH = 5.1) ion release kinetics was much more complex. In LA medium without thymol and/ or carboxymethylcellulose, as a result of unfavorable changes in the internal calcium/phosphate ion stoichiometry, the ion release rate greatly increased but without observable conversion of ACP to apatite.
Journal of Materials Science-Materials in Medicine


amorphous calcium phosphate, composite/hard tissue, ion release, mechanical strength, urethane methacrylates


Regnault, W. , Icenogle, T. , Antonucci, J. and Skrtic, D. (2007), Amorphous Calcium Phosphate/Urethane Methacrylate Resin Composites. I. Physicochemical Characterization, Journal of Materials Science-Materials in Medicine, [online], (Accessed June 24, 2024)


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Created May 7, 2007, Updated February 19, 2017