Simon, C.
, Yang, Y.
, Dorsey, S.
, Ramalingam, M.
and Chatterjee, K.
(2010),
3D Polymer Scaffold Arrays, Humana Press Inc, Totowa, NJ, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=854150
(Accessed April 20, 2024)
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3D Polymer Scaffold Arrays
Published
Author(s)
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Abstract
We have developed a combinatorial platform for screening the effect polymer scaffold properties and composition on cell response. Traditional research involves preparing samples one at a time for characterization and testing. Combinatorial and high-throughput (CHT) methods lower the cost of research by reducing the amount of time and material required for experiments by combining many samples into miniaturized specimens. In order to help accelerate biomaterials research, many new CHT methods have recently been developed for screening cell-material interactions. However, biomaterials are frequently used to fabricate 3D scaffolds, cells exist in vivo in a 3D environment and cells cultured in a 3D environment in vitro typically behave more physiologically than those cultured on a 2D surface. Thus, we have developed CHT methods for screening cell-material interactions where the materials are presented to cells in a 3D scaffold format.Citation
Methods in Molecular Biology
Volume
671
Publisher Info
Humana Press Inc, Totowa, NJ
Pub Type
Books
Download Paper
Keywords
array, biomaterials, cell adhesion, cell proliferation, combinatorial methods, polymer scaffold, rapid screening
Citation
Created December 5, 2010, Updated February 19, 2017